American GLP-1 Medication Guides

Evidence-based information. Learn about semaglutide, tirzepatide, and other GLP-1 receptor agonists. We review clinical trial data, dosing protocols, side effect profiles, and real-world effectiveness.

Semaglutide

★★★★

Marketed as Ozempic (diabetes) and Wegovy (weight management). STEP trial data shows 14.9% average weight loss at 68 weeks. Weekly subcutaneous injection.

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Tirzepatide

★★★★★

Marketed as Mounjaro (diabetes) and Zepbound (weight management). SURMOUNT-1 trial showed 20.9% average weight loss. Dual GIP/GLP-1 agonist, weekly injection.

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Orforglipron (Foundayo)

NEW — APPROVED APRIL 2026

The first non-peptide GLP-1 pill for chronic weight management, and the only one taken once daily with no food or water restrictions. Average weight loss of 11.1% at the top dose over 72 weeks — less than the injectables, in exchange for losing the needle.

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The GLP-1 Pills, Compared

Three oral options now exist and they are not interchangeable. Two require a 30-minute fast every morning, one does not, and one is not approved for weight loss at all.

Compare Medications

Side-by-side comparison of efficacy, dosing, costs, and side effects across GLP-1 medications.

Side Effects Guide

Common and serious side effects, frequency data from trials, and management strategies.

Cost Guide

Pricing breakdown, insurance coverage, savings programs, and telehealth alternatives.

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Based on Clinical Trial Data

American scientific standards. Our medication guides cite specific trials, regulatory filings, and peer-reviewed research. We report findings as published—no exaggeration, no cherry-picking.

STEP 1-5

Semaglutide trial program

SURMOUNT

Tirzepatide trial program

68 weeks

Typical trial duration

FDA ★

Approved medications only

🇺🇸Medical Disclaimer

Your health, your doctor. This information is for educational purposes only and does not constitute medical advice. GLP-1 medications require a prescription and medical supervision. We are not healthcare providers. Talk to your doctor about whether these medications are appropriate for your individual health situation, including potential risks, benefits, and alternatives.